3u78

X-ray diffraction
2.69Å resolution

E67-2 selectively inhibits KIAA1718, a human histone H3 lysine 9 Jumonji demethylase

Released:

Function and Biology Details

Reaction catalysed:
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(9) + 2-oxoglutarate + O(2) = a [histone H3]-N(6)-methyl-L-lysine(9) + succinate + formaldehyde + CO(2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysine-specific demethylase 7A Chain: A
Molecule details ›
Chain: A
Length: 397 amino acids
Theoretical weight: 46.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6ZMT4 (Residues: 92-488; Coverage: 42%)
Gene names: JHDM1D, KDM7, KDM7A, KIAA1718
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P6122
Unit cell:
a: 77.429Å b: 77.429Å c: 289.685Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.198 0.264
Expression system: Escherichia coli