X-ray diffraction
1.75Å resolution

Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (FabG)(G92D) from Vibrio cholerae


Function and Biology Details

Reaction catalysed:
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
3-oxoacyl-[acyl-carrier-protein] reductase FabG Chains: A, B
Molecule details ›
Chains: A, B
Length: 251 amino acids
Theoretical weight: 26.42 KDa
Source organism: Vibrio cholerae O1 biovar El Tor str. N16961
Expression system: Escherichia coli
  • Canonical: Q9KQH7 (Residues: 1-244; Coverage: 100%)
Gene names: VC_2021, fabG
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P62
Unit cell:
a: 63.574Å b: 63.574Å c: 191.059Å
α: 90° β: 90° γ: 120°
R R work R free
0.161 0.16 0.187
Expression system: Escherichia coli