3twu

X-ray diffraction
1.8Å resolution

Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human MCL1

Released:

Function and Biology Details

Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Poly [ADP-ribose] polymerase tankyrase-2 Chain: A
Molecule details ›
Chain: A
Length: 167 amino acids
Theoretical weight: 18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H2K2 (Residues: 488-649; Coverage: 14%)
Gene names: PARP5B, TANK2, TNKL, TNKS2
Sequence domains:
Structure domains: Ankyrin repeat-containing domain
Induced myeloid leukemia cell differentiation protein Mcl-1 Chain: B
Molecule details ›
Chain: B
Length: 16 amino acids
Theoretical weight: 1.72 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q07820 (Residues: 73-88; Coverage: 5%)
Gene names: BCL2L3, MCL1

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 34.702Å b: 45.759Å c: 95.662Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.228
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided