3tob

X-ray diffraction
2.7Å resolution

Human MOF E350Q crystal structure with active site lysine partially acetylated

Released:

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT8 Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 35.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H7Z6 (Residues: 177-458; Coverage: 62%)
Gene names: KAT8, MOF, MYST1, PP7073
Sequence domains: MOZ/SAS family
Structure domains:

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P212121
Unit cell:
a: 45.971Å b: 58.042Å c: 120.338Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.203 0.252
Expression system: Escherichia coli