3toa

X-ray diffraction
3Å resolution

Human MOF crystal structure with active site lysine partially acetylated

Released:

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT8 Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 35.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H7Z6 (Residues: 177-458; Coverage: 62%)
Gene names: KAT8, MOF, MYST1, PP7073
Sequence domains: MOZ/SAS family
Structure domains:

Ligands and Environments

3 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 46.255Å b: 58.534Å c: 121.501Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.246 0.265
Expression system: Escherichia coli