› 3to2

X-ray diffraction
2.6Å resolution

Structure of HLA-A*0201 complexed with peptide Md3-C9 derived from a clustering region of restricted cytotoxic T lymphocyte epitope from SARS-CoV M protein

Released:
DOI: 10.2210/pdb3to2/pdb
PDB entry 3to2 coloured by chain, front view.
PDB entry 3to2 coloured by chain, side view.
PDB entry 3to2 coloured by chain, top view.
Source organisms:
Primary publication:
Functional and Structural Definition of a Clustering Region of HLA-A2-restricted Cytotoxic T Lymphocyte Epitopes
Liu J, Qi J, Gao F, Yan J, Gao GF
Ke Ji Dao Bao 29 19-26 (2011)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-157825 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q53Z42 (Residues: 25-299; Coverage: 81%)
Gene name: HLA-A
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Membrane protein Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 906 Da
Source organism: SARS coronavirus TJF
Expression system: Not provided
UniProt:
  • Canonical: P59596 (Residues: 61-69; Coverage: 4%)
Gene names: 5, M

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P63
Unit cell:
a: 147.459Å b: 147.459Å c: 49.903Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.193 0.23
Expression systems:
  • Escherichia coli
  • Not provided

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