PDBe 3t3x

X-ray diffraction
1.57Å resolution

1.57 A structure of Friedreich's ataxia frataxin variant R165C

Released:

Function and Biology Details

Reaction catalysed:
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Frataxin mature form Chains: A, B
Molecule details ›
Chains: A, B
Length: 129 amino acids
Theoretical weight: 14.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16595 (Residues: 82-210; Coverage: 61%)
  • Best match: Q16595-3 (Residues: 82-160)
Gene names: FRDA, FXN, X25
Sequence domains: Frataxin-like domain
Structure domains: Frataxin/CyaY

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: C2
Unit cell:
a: 86.02Å b: 32.12Å c: 92.08Å
α: 90° β: 90.16° γ: 90°
R-values:
R R work R free
0.218 0.216 0.251
Expression system: Escherichia coli