PDBe 3t3s

X-ray diffraction
3Å resolution

Human Cytochrome P450 2A13 in complex with Pilocarpine

Released:

Function and Biology Details

Reaction catalysed:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 2A13 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 476 amino acids
Theoretical weight: 54.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16696 (Residues: 31-494; Coverage: 94%)
Gene name: CYP2A13
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments


Cofactor: Ligand HEM 8 x HEM
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P1
Unit cell:
a: 71.501Å b: 119.862Å c: 154.871Å
α: 101.01° β: 101.72° γ: 93.59°
R-values:
R R work R free
0.218 0.213 0.303
Expression system: Escherichia coli