PDBe 3t2n

X-ray diffraction
2.55Å resolution

Human hepsin protease in complex with the Fab fragment of an inhibitory antibody

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Serine protease hepsin catalytic chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 372 amino acids
Theoretical weight: 40.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05981 (Residues: 46-417; Coverage: 89%)
Gene names: HPN, TMPRSS1
Sequence domains:
Structure domains:
Antibody, Fab fragment, Heavy Chain Chains: H, I
Molecule details ›
Chains: H, I
Length: 225 amino acids
Theoretical weight: 23.97 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins
Antibody, Fab fragment, Light Chain Chains: L, M
Molecule details ›
Chains: L, M
Length: 215 amino acids
Theoretical weight: 22.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P1
Unit cell:
a: 62.98Å b: 66.58Å c: 108.33Å
α: 88.71° β: 94.3° γ: 104.53°
R-values:
R R work R free
0.244 0.242 0.275
Expression systems:
  • Homo sapiens
  • Not provided