PDBe 3syq

X-ray diffraction
3.44Å resolution

Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) R201A mutant in complex with PIP2


Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
G protein-activated inward rectifier potassium channel 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 340 amino acids
Theoretical weight: 38.98 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
  • Canonical: P48542 (Residues: 52-380; Coverage: 77%)
  • Best match: P48542-3 (Residues: 52-318)
Gene names: Girk2, Kcnj6, Kcnj7, W
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2221
Unit cell:
a: 87.605Å b: 208.491Å c: 117.376Å
α: 90° β: 90° γ: 90°
R R work R free
0.301 0.3 0.323
Expression system: Komagataella pastoris