X-ray diffraction
2.31Å resolution

Human MPP8 - human DNMT3AK47me2 peptide


Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
M-phase phosphoprotein 8 Chain: A
Molecule details ›
Chain: A
Length: 62 amino acids
Theoretical weight: 7.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q99549 (Residues: 55-116; Coverage: 7%)
Gene names: MPHOSPH8, MPP8
Sequence domains: Chromo (CHRromatin Organisation MOdifier) domain
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
DNA (cytosine-5)-methyltransferase 3A Chain: P
Molecule details ›
Chain: P
Length: 15 amino acids
Theoretical weight: 1.71 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q9Y6K1 (Residues: 40-53; Coverage: 2%)
Gene name: DNMT3A

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: I222
Unit cell:
a: 41.09Å b: 43.9Å c: 90.28Å
α: 90° β: 90° γ: 90°
R R work R free
0.257 0.257 0.272
Expression systems:
  • Escherichia coli
  • Not provided