PDBe 3sek

X-ray diffraction
2.4Å resolution

Crystal Structure of the Myostatin:Follistatin-like 3 Complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth/differentiation factor 8 Chain: B
Molecule details ›
Chain: B
Length: 109 amino acids
Theoretical weight: 12.42 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: O08689 (Residues: 268-376; Coverage: 31%)
Gene names: Gdf8, Mstn
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Follistatin-related protein 3 Chain: C
Molecule details ›
Chain: C
Length: 209 amino acids
Theoretical weight: 22.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O95633 (Residues: 36-244; Coverage: 88%)
Gene names: FLRG, FSTL3, UNQ674/PRO1308
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P6122
Unit cell:
a: 82.086Å b: 82.086Å c: 312.691Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.247 0.246 0.27
Expression systems:
  • Cricetulus griseus
  • Homo sapiens