› 3rw7

X-ray diffraction
3Å resolution

Structure of N-terminal domain of nuclear RNA export factor TAP

Released:
DOI: 10.2210/pdb3rw7/pdb
PDB entry 3rw7 coloured by chain, front view.
PDB entry 3rw7 coloured by chain, side view.
PDB entry 3rw7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP.
Teplova M, Wohlbold L, Khin NW, Izaurralde E, Patel DJ
Nat Struct Mol Biol 18 990-8 (2011)
PMID: 21822283

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193679 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear RNA export factor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 267 amino acids
Theoretical weight: 30.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UBU9 (Residues: 96-362; Coverage: 43%)
Gene names: NXF1, TAP
Sequence domains: Tap, RNA-binding
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P41212
Unit cell:
a: 139.373Å b: 139.373Å c: 207.113Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.262 0.26 0.31
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

The role of TREX in gene expression and disease.
Heath et al. (2016)
6 more

4 mentions without citation

Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP.
Teplova et al. (2011)
3 more