› 3rc3

X-ray diffraction
2.08Å resolution

Human Mitochondrial Helicase Suv3

Released:
DOI: 10.2210/pdb3rc3/pdb
PDB entry 3rc3 coloured by chain, front view.
PDB entry 3rc3 coloured by chain, side view.
PDB entry 3rc3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human Suv3 protein reveals unique features among SF2 helicases.
Jedrzejczak R, Wang J, Dauter M, Szczesny RJ, Stepien PP, Dauter Z
Acta Crystallogr D Biol Crystallogr 67 988-96 (2011)
PMID: 22101826

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184936 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent RNA helicase SUPV3L1, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 677 amino acids
Theoretical weight: 76.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IYB8 (Residues: 47-722; Coverage: 86%)
Gene names: SUPV3L1, SUV3
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand ANP 1 x ANP
Ligand NA 1 x NA
Ligand AZI 1 x AZI
Ligand CL 1 x CL
1 modified residue:
Ligand MSE 14 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P32
Unit cell:
a: 89.39Å b: 89.39Å c: 88.07Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.161 0.16 0.203
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Ski2-like RNA helicase structures: common themes and complex assemblies.
Johnson et al. (2013)
5 more

5 mentions without citation

TWINKLE and Other Human Mitochondrial DNA Helicases: Structure, Function and Disease.
Peter et al. (2020)
4 more