3qxy

X-ray diffraction
2.09Å resolution

Human SETD6 in complex with RelA Lys310

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
N-lysine methyltransferase SETD6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 449 amino acids
Theoretical weight: 50.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TBK2 (Residues: 1-473; Coverage: 95%)
  • Best match: Q8TBK2-2 (Residues: 1-449)
Gene name: SETD6
Sequence domains:
Structure domains:
Transcription factor p65 Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 15 amino acids
Theoretical weight: 1.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q04206 (Residues: 302-316; Coverage: 3%)
Gene names: NFKB3, RELA

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P1
Unit cell:
a: 61.464Å b: 64.985Å c: 73.891Å
α: 78.33° β: 70.05° γ: 63.75°
R-values:
R R work R free
0.173 0.171 0.229
Expression systems:
  • Escherichia coli
  • Not provided