X-ray diffraction
2.3Å resolution

Recognition of the F&H motif by the Lowe Syndrome protein OCRL

Source organism: Homo sapiens
Primary publication:
Recognition of the F&H motif by the Lowe syndrome protein OCRL.
Nat. Struct. Mol. Biol. 18 789-95 (2011)
PMID: 21666675

Function and Biology Details

Reactions catalysed:
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Inositol polyphosphate 5-phosphatase OCRL Chain: A
Molecule details ›
Chain: A
Length: 366 amino acids
Theoretical weight: 42.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q01968 (Residues: 536-901; Coverage: 41%)
Gene names: OCRL, OCRL1
Sequence domains: RhoGAP domain
Structure domains:
Sesquipedalian-1 Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.56 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q8N4B1 (Residues: 223-235; Coverage: 5%)
Gene names: FAM109A, PHETA1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P3121
Unit cell:
a: 73.478Å b: 73.478Å c: 145.294Å
α: 90° β: 90° γ: 120°
R R work R free
0.198 0.195 0.238
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided