X-ray diffraction
1.4Å resolution

Crystal Structure of NADPH-Cytochrome P450 Reductase (FAD/NADPH domain)

Source organism: Homo sapiens
Primary publication:
Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.
Proc. Natl. Acad. Sci. U.S.A. 108 13486-91 (2011)
PMID: 21808038

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
NADPH--cytochrome P450 reductase Chain: A
Molecule details ›
Chain: A
Length: 458 amino acids
Theoretical weight: 52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P16435 (Residues: 241-677; Coverage: 65%)
Gene names: CYPOR, POR
Sequence domains:
Structure domains:

Ligands and Environments

Cofactor: Ligand NAP 1 x NAP

Cofactor: Ligand FAD 1 x FAD
No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 54.64Å b: 58.54Å c: 130.28Å
α: 90° β: 90° γ: 90°
R R work R free
0.211 0.211 0.231
Expression system: Escherichia coli