3pq1

X-ray diffraction
3.1Å resolution

Crystal structure of human mitochondrial poly(A) polymerase (PAPD1)

Released:

Function and Biology Details

Reaction catalysed:
ATP + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Poly(A) RNA polymerase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 464 amino acids
Theoretical weight: 52.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NVV4 (Residues: 44-538; Coverage: 76%)
Gene names: MTPAP, PAPD1
Sequence domains:

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 68.68Å b: 76.88Å c: 87.63Å
α: 90° β: 103.39° γ: 90°
R-values:
R R work R free
0.251 0.247 0.328
Expression system: Escherichia coli