X-ray diffraction
1.8Å resolution

Crystal structure of MLLE domain of poly(A) binding protein in complex with PAM2 motif of La-related protein 4 (LARP4)


Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
Non-polymer only dimer (preferred)
Non-polymer only tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Polyadenylate-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 88 amino acids
Theoretical weight: 9.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P11940 (Residues: 544-626; Coverage: 13%)
Gene names: PAB1, PABP1, PABPC1, PABPC2
Sequence domains: Poly-adenylate binding protein, unique domain
Structure domains: c-terminal domain of poly(a) binding protein
La-related protein 4 Chain: B
Molecule details ›
Chain: B
Length: 14 amino acids
Theoretical weight: 1.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q71RC2 (Residues: 13-26; Coverage: 2%)
Gene names: LARP4, PP13296

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: C2
Unit cell:
a: 48.91Å b: 31.384Å c: 52.647Å
α: 90° β: 104.95° γ: 90°
R R work R free
0.227 0.225 0.269
Expression systems:
  • Escherichia coli
  • Not provided