3pg9

X-ray diffraction
2.35Å resolution

Thermotoga maritima DAH7P synthase in complex with inhibitor

Released:

Function and Biology Details

Reaction catalysed:
Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phospho-2-dehydro-3-deoxyheptonate aldolase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 338 amino acids
Theoretical weight: 37.43 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9WYH8 (Residues: 1-338; Coverage: 100%)
Gene names: TM_0343, aroF
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 81.61Å b: 121.002Å c: 133.379Å
α: 90° β: 92.12° γ: 90°
R-values:
R R work R free
0.172 0.171 0.222
Expression system: Escherichia coli