X-ray diffraction
1.8Å resolution

Structure of Sir2Tm bound to a propionylated peptide

Primary publication:
Structure of Sir2Tm bound to a propionylated peptide.
Protein Sci. 20 131-9 (2011)
PMID: 21080423

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NAD-dependent protein deacetylase Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 27.57 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
  • Canonical: Q9WYW0 (Residues: 1-246; Coverage: 100%)
Gene names: TM_0490, cobB, sir2
Sequence domains: Sir2 family
Structure domains:
Cellular tumor antigen p53 Chain: D
Molecule details ›
Chain: D
Length: 18 amino acids
Theoretical weight: 2.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P04637 (Residues: 372-389; Coverage: 5%)
Gene names: P53, TP53

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P212121
Unit cell:
a: 46.561Å b: 60.013Å c: 106.345Å
α: 90° β: 90° γ: 90°
R R work R free
0.167 0.165 0.21
Expression systems:
  • Escherichia coli
  • Not provided