3p8x

X-ray diffraction
1.7Å resolution

Synthesis, Structure, and Biological Activity of des-Side Chain Analogues of 1alpha,25-Dihydroxyvitamin D3 with Substituents at C-18

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vitamin D3 receptor Chain: A
Molecule details ›
Chain: A
Length: 280 amino acids
Theoretical weight: 31.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P11473 (Residues: 118-164, 217-427; Coverage: 60%)
Gene names: NR1I1, VDR
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 44.628Å b: 51.342Å c: 130.82Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.189 0.209
Expression system: Escherichia coli BL21