› 3p4k

X-ray diffraction
2.3Å resolution

The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution

Released:
DOI: 10.2210/pdb3p4k/pdb
PDB entry 3p4k coloured by chain, front view.
PDB entry 3p4k coloured by chain, side view.
PDB entry 3p4k coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The third conformation of p38α MAP kinase observed in phosphorylated p38α and in solution.
Akella R, Min X, Wu Q, Gardner KH, Goldsmith EJ
Structure 18 1571-8 (2010)
PMID: 21134636

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155652 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 370 amino acids
Theoretical weight: 42.56 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P47811 (Residues: 1-360; Coverage: 100%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Sequence domains: Protein kinase domain
Structure domains:
MAP kinase 14 Chain: P
Molecule details ›
Chain: P
Length: 11 amino acids
Theoretical weight: 1.18 KDa
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3121
Unit cell:
a: 82.641Å b: 82.641Å c: 123.64Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.176 0.239
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

2 review citations

MAP kinase modules: the excursion model and the steps that count.
Piala et al. (2014)
1 more

4 mentions without citation

Molecular basis of MAP kinase regulation.
Peti et al. (2013)
3 more