PDBe 3omh

X-ray diffraction
2.9Å resolution

Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 22 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 313 amino acids
Theoretical weight: 36.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y2R2 (Residues: 1-294; Coverage: 36%)
Gene names: PTPN22, PTPN8
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily
Src kinase-associated phosphoprotein 2 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 9 amino acids
Theoretical weight: 1.17 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O75563 (Residues: 71-79; Coverage: 3%)
Gene names: PRAP, RA70, SAPS, SCAP2, SKAP2, SKAP55R

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 115.229Å b: 46.707Å c: 121.493Å
α: 90° β: 101.43° γ: 90°
R-values:
R R work R free
0.231 0.229 0.26
Expression systems:
  • Escherichia coli
  • Not provided