PDBe 3od0

X-ray diffraction
2.9Å resolution

Crystal structure of cGMP bound cGMP-dependent protein kinase(92-227)

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cGMP-dependent protein kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 139 amino acids
Theoretical weight: 15.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13976 (Residues: 84-212; Coverage: 19%)
  • Best match: Q13976-2 (Residues: 92-227)
Gene names: PRKG1, PRKG1B, PRKGR1A, PRKGR1B
Sequence domains: Cyclic nucleotide-binding domain
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P6222
Unit cell:
a: 107.625Å b: 107.625Å c: 171.391Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.26
Expression system: Escherichia coli BL21(DE3)