X-ray diffraction
1.4Å resolution

Crystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor susceptibility gene 101 protein Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 16.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q99816 (Residues: 2-145; Coverage: 36%)
Gene name: TSG101
Sequence domains: UEV domain
Structure domains: Ubiquitin Conjugating Enzyme
Hepatocyte growth factor-regulated tyrosine kinase substrate Chain: B
Molecule details ›
Chain: B
Length: 9 amino acids
Theoretical weight: 878 Da
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: O14964 (Residues: 346-354; Coverage: 1%)
Gene names: HGS, HRS

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 33.654Å b: 45.126Å c: 87.734Å
α: 90° β: 90° γ: 90°
R R work R free
0.21 0.207 0.224
Expression systems:
  • Escherichia coli
  • Not provided