X-ray diffraction
2.92Å resolution

Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with AMP

Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
G protein-coupled receptor kinase 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 576 amino acids
Theoretical weight: 65.98 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
  • Canonical: P43250 (Residues: 2-576; Coverage: 100%)
Gene names: GPRK6, GRK6
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P61
Unit cell:
a: 154.574Å b: 154.574Å c: 208.117Å
α: 90° β: 90° γ: 120°
R R work R free
0.222 0.222 0.253
Expression system: Trichoplusia ni