X-ray diffraction
2.2Å resolution

Crystal structure of human prethrombin-1

Source organism: Homo sapiens
Primary publication:
Crystal structure of prethrombin-1.
Proc. Natl. Acad. Sci. U.S.A. 107 19278-83 (2010)
PMID: 20974933

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Prothrombin Chain: A
Molecule details ›
Chain: A
Length: 424 amino acids
Theoretical weight: 47.84 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
  • Canonical: P00734 (Residues: 199-622; Coverage: 71%)
Gene name: F2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 67.893Å b: 81.006Å c: 88.463Å
α: 90° β: 90° γ: 90°
R R work R free
0.199 0.198 0.226
Expression system: Cricetulus griseus