3nvq

X-ray diffraction
2.4Å resolution

Molecular mechanism of guidance cue recognition

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Semaphorin-7A Chains: A, E
Molecule details ›
Chains: A, E
Length: 590 amino acids
Theoretical weight: 67.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75326 (Residues: 45-634; Coverage: 95%)
Gene names: CD108, SEMA7A, SEMAL
Sequence domains:
Structure domains:
Plexin-C1 Chains: B, F
Molecule details ›
Chains: B, F
Length: 476 amino acids
Theoretical weight: 51.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60486 (Residues: 35-507; Coverage: 31%)
Gene names: PLXNC1, VESPR
Sequence domains: Plexin repeat

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 99.645Å b: 126.078Å c: 236.419Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.248 0.277
Expression system: Homo sapiens