PDBe 3nru

X-ray diffraction
2.3Å resolution

Ligand binding domain of EPHA7

Released:
Source organism: Homo sapiens
Entry authors: Walker JR, Yermekbayeva L, Seitova A, Kania J, Bountra C, Weigelt J, Arrowsmith CH, Edwards AM, Bochkarev A, Dhe-Paganon S

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 7 Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 187 amino acids
Theoretical weight: 21.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15375 (Residues: 32-204; Coverage: 18%)
Gene names: EHK3, EPHA7, HEK11
Structure domains: Galactose-binding domain-like

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 137.617Å b: 140.699Å c: 143.783Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.235 0.269
Expression system: Spodoptera frugiperda