PDBe 3n93

X-ray diffraction
2.5Å resolution

Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 3

Source organism: Homo sapiens
Entry authors: Pal K, Swaminathan K, Pioszak AA, Xu HE

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero hexamer
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Maltose binding protein-CRFR2 alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 482 amino acids
Theoretical weight: 53.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains:
Urocortin-3 Chain: C
Molecule details ›
Chain: C
Length: 17 amino acids
Theoretical weight: 1.69 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q969E3 (Residues: 142-157; Coverage: 11%)
Gene names: SPC, UCN3

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: C2221
Unit cell:
a: 54.278Å b: 208.513Å c: 212.55Å
α: 90° β: 90° γ: 90°
R R work R free
0.222 0.22 0.266
Expression systems:
  • Escherichia coli
  • Not provided