3n40

X-ray diffraction
2.17Å resolution

Crystal structure of the immature envelope glycoprotein complex of Chikungunya virus.

Released:

Function and Biology Details

Reaction catalysed:
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Togavirin Chain: P
Molecule details ›
Chain: P
Length: 401 amino acids
Theoretical weight: 45.34 KDa
Source organism: Chikungunya virus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q1H8W5 (Residues: 266-666; Coverage: 32%)
Sequence domains: Alphavirus E3 glycoprotein
Structure domains:
Togavirin Chain: F
Molecule details ›
Chain: F
Length: 393 amino acids
Theoretical weight: 42.67 KDa
Source organism: Chikungunya virus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q1H8W5 (Residues: 808-1200; Coverage: 32%)
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, NDG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P212121
Unit cell:
a: 58.74Å b: 90.01Å c: 179.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.208 0.239
Expression system: Drosophila melanogaster