PDBe 3mwu

X-ray diffraction
1.98Å resolution

Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calmodulin-domain protein kinase 1, putative Chain: A
Molecule details ›
Chain: A
Length: 486 amino acids
Theoretical weight: 56.15 KDa
Source organism: Cryptosporidium parvum Iowa II
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A3FQ16 (Residues: 70-538; Coverage: 87%)
Gene name: cgd3_920
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 60.02Å b: 55.97Å c: 82.21Å
α: 90° β: 104.79° γ: 90°
R-values:
R R work R free
0.196 0.194 0.229
Expression system: Escherichia coli BL21(DE3)