PDBe 3mi8

X-ray diffraction
2.95Å resolution

The structure of TL1A-DCR3 COMPLEX

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor ligand superfamily member 15, secreted form Chain: A
Molecule details ›
Chain: A
Length: 184 amino acids
Theoretical weight: 20.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O95150 (Residues: 72-251; Coverage: 72%)
Gene names: TL1, TNFSF15, VEGI
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 6B Chain: D
Molecule details ›
Chain: D
Length: 176 amino acids
Theoretical weight: 19.29 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: O95407 (Residues: 30-195; Coverage: 61%)
Gene names: DCR3, TNFRSF6B, TR6, UNQ186/PRO212
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P4332
Unit cell:
a: 161.08Å b: 161.08Å c: 161.08Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.261
Expression systems:
  • Escherichia coli BL21
  • Drosophila