X-ray diffraction
2.2Å resolution

CASK-4M CaM Kinase Domain, Mn2+

Source organism: Homo sapiens
Primary publication:
Evolution of CASK into a Mg2+-sensitive kinase.
Sci Signal 3 ra33 (2010)
PMID: 20424264

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Peripheral plasma membrane protein CASK Chain: A
Molecule details ›
Chain: A
Length: 351 amino acids
Theoretical weight: 39.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O14936 (Residues: 1-337; Coverage: 36%)
Gene names: CASK, LIN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P212121
Unit cell:
a: 58.943Å b: 61.811Å c: 101.463Å
α: 90° β: 90° γ: 90°
R R work R free
0.214 0.21 0.27
Expression system: Escherichia coli