X-ray diffraction
1.9Å resolution

Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide


Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Signal-transducing adaptor protein 1 Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9ULZ2 (Residues: 167-285; Coverage: 40%)
Gene names: BRDG1, STAP1
Sequence domains: SH2 domain
Structure domains: SH2 domain
Linker for activation of T-cells family member 2 Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.3 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q9GZY6 (Residues: 133-143; Coverage: 5%)
Gene names: HSPC046, LAB, LAT2, NTAL, WBS15, WBSCR15, WBSCR5

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P6222
Unit cell:
a: 72.64Å b: 72.64Å c: 97.84Å
α: 90° β: 90° γ: 120°
R R work R free
0.225 0.212 0.236
Expression systems:
  • Escherichia coli
  • Not provided