PDBe 3lq8

X-ray diffraction
2.02Å resolution

Structure of the kinase domain of c-Met bound to XL880 (GSK1363089)


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Hepatocyte growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 302 amino acids
Theoretical weight: 34.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P08581 (Residues: 1051-1348; Coverage: 22%)
Gene name: MET
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 37.925Å b: 43.017Å c: 89.618Å
α: 90° β: 91.61° γ: 90°
R R work R free
0.194 0.191 0.252
Expression system: Spodoptera frugiperda