3lq5

X-ray diffraction
3Å resolution

Structure of CDK9/CyclinT in complex with S-CR8

Released:

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-dependent kinase 9 Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 38.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P50750 (Residues: 2-330; Coverage: 88%)
Gene names: CDC2L4, CDK9, TAK
Sequence domains: Protein kinase domain
Structure domains:
Cyclin-T1 Chain: B
Molecule details ›
Chain: B
Length: 260 amino acids
Theoretical weight: 30.12 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60563 (Residues: 2-259; Coverage: 36%)
Gene name: CCNT1
Sequence domains: Cyclin, N-terminal domain
Structure domains: Cyclin-like

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: R3
Unit cell:
a: 173.249Å b: 173.249Å c: 99.241Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.165 0.162 0.215
Expression system: Spodoptera frugiperda