3lny

X-ray diffraction
1.3Å resolution

Second PDZ domain from human PTP1E in complex with RA-GEF2 peptide

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
Non-polymer only dodecamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 13 Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 10.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12923 (Residues: 1361-1456; Coverage: 4%)
Gene names: PNP1, PTP1E, PTPL1, PTPN13
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Rap guanine nucleotide exchange factor 6 Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 632 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8TEU7 (Residues: 1596-1601; Coverage: 0%)
Gene names: PDZGEF2, RAPGEF6

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: R32
Unit cell:
a: 73.965Å b: 73.965Å c: 134.056Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.164 0.163 0.189
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided