› 3ljz

X-ray diffraction
2Å resolution

Crystal Structure of Human MMP-13 complexed with an Amino-2-indanol compound

Released:
DOI: 10.2210/pdb3ljz/pdb
PDB entry 3ljz coloured by chain, front view.
PDB entry 3ljz coloured by chain, side view.
PDB entry 3ljz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure analysis reveals the flexibility of the ADAMTS-5 active site.
Shieh HS, Tomasselli AG, Mathis KJ, Schnute ME, Woodard SS, Caspers N, Williams JM, Kiefer JR, Munie G, Wittwer A, Malfait AM, Tortorella MD
Protein Sci 20 735-44 (2011)
PMID: 21370305

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155286 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collagenase 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 164 amino acids
Theoretical weight: 18.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P45452 (Residues: 104-267; Coverage: 36%)
Gene name: MMP13
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

5 bound ligands:
Ligand CA 8 x CA
Ligand ZN 8 x ZN
Ligand SO4 9 x SO4
Ligand LA3 4 x LA3
Ligand EPE 4 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 73.604Å b: 94.927Å c: 120.406Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.202 0.228
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Emerging roles for ADAMTS5 during development and disease.
Kintakas et al. (2011)
1 more