3liy

X-ray diffraction
1.86Å resolution

crystal structure of HTLV protease complexed with Statine-containing peptide inhibitor

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidase A2 domain-containing protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 116 amino acids
Theoretical weight: 12.57 KDa
Source organism: Human T-cell leukemia virus type I
Expression system: Escherichia coli
UniProt:
  • Canonical: Q82134 (Residues: 1-116; Coverage: 93%)
Gene name: prt
Sequence domains: Retroviral aspartyl protease
Structure domains: Acid Proteases
statine-containing inhibitor Chains: I, J, K
Molecule details ›
Chains: I, J, K
Length: 10 amino acids
Theoretical weight: 1.06 KDa
Source organism: Human T-cell leukemia virus type I
Expression system: Not provided

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 133.69Å b: 77.395Å c: 80.166Å
α: 90° β: 99.69° γ: 90°
R-values:
R R work R free
0.189 0.188 0.222
Expression systems:
  • Escherichia coli
  • Not provided