3lh0

X-ray diffraction
1.9Å resolution

Crystal structure of the 53BP1 tandem tudor domain in complex with p53K372me2

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
TP53-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12888 (Residues: 1484-1603; Coverage: 6%)
Gene name: TP53BP1
Structure domains:
DIMETHYLATED p53 LYSINE 372 PEPTIDE Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.23 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: C2
Unit cell:
a: 56.7Å b: 78.28Å c: 36.54Å
α: 90° β: 122.18° γ: 90°
R-values:
R R work R free
0.235 0.221 0.232
Expression systems:
  • Escherichia coli
  • Not provided