3kys

X-ray diffraction
2.8Å resolution

Crystal structure of human YAP and TEAD complex

Released:
Source organism: Homo sapiens
Primary publication:
Structural insights into the YAP and TEAD complex.
Genes Dev. 24 235-40 (2010)
PMID: 20123905

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transcriptional enhancer factor TEF-1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 219 amino acids
Theoretical weight: 25.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P28347 (Residues: 209-426; Coverage: 51%)
Gene names: TCF13, TEAD1, TEF1
Sequence domains: YAP binding domain
Structure domains: Coagulation Factor XIII; Chain A, domain 1
Transcriptional coactivator YAP1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 125 amino acids
Theoretical weight: 13.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P46937 (Residues: 50-171; Coverage: 24%)
Gene names: YAP1, YAP65
Structure domains: Virus Scaffolding Protein; Chain A

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 44.643Å b: 110.503Å c: 165.695Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.228 0.266
Expression system: Escherichia coli BL21(DE3)