PDBe 3kvw

X-ray diffraction
2.28Å resolution

Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand

Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Myrianthopoulos V, Kritsanida M, Magiatis P, Skaltsounis AL, Soundararajan M, Krojer T, Gileadi O, Hapka E, Fedorov O, Berridge G, Wang J, Shrestha L, Vollmar M, von Delft F, Arrowsmith CH, Edwards A, Weigelt J, Bountra C, Mikros E, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Dual specificity tyrosine-phosphorylation-regulated kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 429 amino acids
Theoretical weight: 49.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q92630 (Residues: 146-552; Coverage: 68%)
Gene name: DYRK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P42212
Unit cell:
a: 84.28Å b: 84.28Å c: 149.12Å
α: 90° β: 90° γ: 90°
R R work R free
0.211 0.209 0.26
Expression system: Escherichia coli BL21(DE3)