X-ray diffraction
2.39Å resolution

Structure of KIAA1718, human Jumonji demethylase, in complex with N-oxalylglycine


Function and Biology Details

Reaction catalysed:
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(9) + 2-oxoglutarate + O(2) = a [histone H3]-N(6)-methyl-L-lysine(9) + succinate + formaldehyde + CO(2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Lysine-specific demethylase 7A Chains: A, D
Molecule details ›
Chains: A, D
Length: 488 amino acids
Theoretical weight: 55.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q6ZMT4 (Residues: 1-488; Coverage: 52%)
Gene names: JHDM1D, KDM7, KDM7A, KIAA1718
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 62.7Å b: 125.6Å c: 206.1Å
α: 90° β: 90° γ: 90°
R R work R free
0.216 0.216 0.245
Expression system: Escherichia coli