X-ray diffraction
1.4Å resolution

Crystal structure of the MLLE domain of poly(A)-binding protein in complex with the binding region of Paip2


Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Polyadenylate-binding protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 88 amino acids
Theoretical weight: 9.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P11940 (Residues: 544-626; Coverage: 13%)
Gene names: PAB1, PABP1, PABPC1, PABPC2
Sequence domains: Poly-adenylate binding protein, unique domain
Structure domains: c-terminal domain of poly(a) binding protein
Polyadenylate-binding protein-interacting protein 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 15 amino acids
Theoretical weight: 1.62 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q9BPZ3 (Residues: 109-123; Coverage: 12%)
Gene names: HSPC218, PAIP2, PAIP2A

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P1
Unit cell:
a: 26.396Å b: 31.61Å c: 48.214Å
α: 100.12° β: 92.26° γ: 98.9°
R R work R free
0.179 0.178 0.205
Expression systems:
  • Escherichia coli
  • Not provided