3kn6

X-ray diffraction
2Å resolution

Crystal structure of the C-terminal kinase domain of MSK1

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase alpha-5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 325 amino acids
Theoretical weight: 37.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75582 (Residues: 414-738; Coverage: 41%)
Gene names: MSK1, RPS6KA5
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 51.386Å b: 91.739Å c: 134.945Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.216 0.263
Expression system: Escherichia coli