› 3k66

X-ray diffraction
2.7Å resolution

X-ray crystal structure of the E2 domain of C. elegans APL-1

Released:
DOI: 10.2210/pdb3k66/pdb
PDB entry 3k66 coloured by chain, front view.
PDB entry 3k66 coloured by chain, side view.
PDB entry 3k66 coloured by chain, top view.
Source organism: Caenorhabditis elegans
Primary publication:
Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site.
Hoopes JT, Liu X, Xu X, Demeler B, Folta-Stogniew E, Li C, Ha Y
J Biol Chem 285 2165-73 (2010)
PMID: 19906646

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171242 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta-like protein Chain: A
Molecule details ›
Chain: A
Length: 239 amino acids
Theoretical weight: 28.52 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli
UniProt:
  • Canonical: Q10651 (Residues: 240-478; Coverage: 36%)
Gene names: C42D8.8, apl-1
Sequence domains: E2 domain of amyloid precursor protein
Structure domains: Amyloid precursor protein, E2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3221
Unit cell:
a: 97.621Å b: 97.621Å c: 67.975Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.251 0.251 0.299
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Caenorhabditis elegans as a model organism to study APP function.
Ewald et al. (2012)
13 other articles

1 mention without citation

Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site.
Hoopes et al. (2010)