PDBe 3k51

X-ray diffraction
2.45Å resolution

Crystal Structure of DcR3-TL1A complex

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor ligand superfamily member 15, secreted form Chain: A
Molecule details ›
Chain: A
Length: 184 amino acids
Theoretical weight: 20.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95150 (Residues: 72-251; Coverage: 72%)
Gene names: TL1, TNFSF15, VEGI
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 6B Chain: B
Molecule details ›
Chain: B
Length: 176 amino acids
Theoretical weight: 19.29 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: O95407 (Residues: 30-195; Coverage: 61%)
Gene names: DCR3, TNFRSF6B, TR6, UNQ186/PRO212
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P321
Unit cell:
a: 74.89Å b: 74.89Å c: 143.125Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.223 0.262
Expression systems:
  • Escherichia coli
  • Drosophila