X-ray diffraction
2.4Å resolution

BimL12Y in complex with Mcl-1


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1; Induced myeloid leukemia cell differentiation protein Mcl-1 homolog Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 18.23 KDa
Source organisms: Expression system: Escherichia coli BL21
  • Canonical: P97287 (Residues: 152-221; Coverage: 21%)
  • Canonical: Q07820 (Residues: 241-327; Coverage: 25%)
Gene names: BCL2L3, MCL1, Mcl1
Structure domains: Blc2-like
Bcl-2-like protein 11 Chain: B
Molecule details ›
Chain: B
Length: 26 amino acids
Theoretical weight: 3.32 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: O43521 (Residues: 141-166; Coverage: 13%)
Gene names: BCL2L11, BIM

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: I222
Unit cell:
a: 52.537Å b: 74.119Å c: 117.541Å
α: 90° β: 90° γ: 90°
R R work R free
0.211 0.209 0.251
Expression systems:
  • Escherichia coli BL21
  • Not provided